Diet-induced weight loss reduces postprandial dicarbonyl stress in abdominally obese men: Secondary analysis of a randomized controlled trial

AimsDicarbonyl compounds contribute to the formation of advanced glycation endproducts (AGEs) and development insulin resistance vascular complications. Dicarbonyl stress may already be detrimental in obesity. We evaluated whether diet-induced weight loss can effectively reverse dicarbonyl abdominally obese men.Materials methodsPlasma samples were collected from lean (n = 25) men 52) fasting state, during a mixed meal test (MMT). Abdominally randomized 8 weeks dietary or habitual diet, followed by second MMT. The α-dicarbonyls methylglyoxal (MGO), glyoxal (GO) 3-deoxyglucosone (3-DG) AGEs measured UPLC-MS/MS. Skin autofluorescence (SAF) was using AGE reader. T-tests used for cross-sectional analysis ANCOVA assess treatment effect.ResultsPostprandial glucose, MGO 3-DG concentrations higher as compared (p < 0.05 all). Fasting dicarbonyls, AGEs, SAF not different between men. After intervention, levels tended decrease 25 nmol/L (95%-CI: -51-0.5; p 0.054). Postprandial dicarbonyls decreased after control group: iAUC 57% (5280 nmol/L∙min; 95%-CI: 33–10526; 0.049), GO 66% (11,329 495–22162; 0.041), 45% (20,175 5351–35000; 0.009). did change significantly loss.ConclusionAbdominal obesity is characterized increased postprandial stress, which reduced intervention.Registered under ClinicalTrials.gov Identifier no. NCT01675401. Plasma effect. loss. Abdominal intervention.